Lethal Enforcers has six stages (including the Training Stage): 'The Bank Robbery', 'Chinatown Assault', 'Hijacking', 'The Drug Dealers', and 'Chemical Plant Sabotage'. When the player loses all lives, the game will be over unless he/she chooses to continue. When the player loses a life, his/her weapon reverts to the basic service revolver.

The submachine gun and grenade launcher can only be used once while other weapons can be reloaded like the basic service revolver. Initially armed with a standard-issue service revolver, the player can acquire upgraded weapons during the course of play: a .357 Magnum, a semi-automatic pistol, a combat shotgun, an assault rifle, a submachine gun, or a grenade launcher. He has been assigned and agrees to help stop a growing crime wave that puts the city's security in serious jeopardy, along with a helper (a second player can join in). From that point on, he is going to experience the toughest job that he would have during his years in the police force. Once the call ended, he decided to check out the bank. The rest have ended up in the hospital or killed. He is one of the two survivors of the elite group of officers. They said that a major crime organization has invaded town, and they need his help. While sipping the last drop of coffee, he gets a call from the police department. Set in Chicago, Illinois, United States, the player takes control of a police officer named Don Marshall, who has one day decided to go to the donut shop for a break.

Lethal enforcers snes box art